Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5467834 | 0.82 | KDM4E (0.46) | MAP4K4GBA1PTPN11ALDH1A1LMNA | |
| SCHEMBL978369 | 0.80 | MAP4K4 (0.46) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL13996889 | 0.80 | PTPN11 (0.48) | MAP4K4SMARCA2SMARCA4PBRM1PTPN11 | |
| SCHEMBL655402 | 0.79 | MAP4K4 (0.46) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL654787 | 0.78 | MAP4K4 (0.45) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL14697627 | 0.77 | LMNA (0.56) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL14941987 | 0.77 | MAP4K4 (0.41) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL20507720 | 0.73 | MAP4K4 (0.48) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL18282608 | 0.73 | SMARCA2 (0.49) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 | |
| SCHEMBL1030947 | 0.72 | HRH4 (0.61) | MAP4K4SMARCA2SMARCA4PBRM1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |