Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900722 | 0.83 | THRB (0.46) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL7778636 | 0.81 | — | — | |
| SCHEMBL350840 | 0.80 | TSHR (0.53) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL7206346 | 0.79 | MEN1 (0.52) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL20262946 | 0.79 | MEN1 (0.52) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL28238169 | 0.79 | TSHR (0.41) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL795575 | 0.77 | USP2 (0.48) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL30519837 | 0.77 | TSHR (0.39) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL28185130 | 0.77 | TSHR (0.39) | TSHRMAPK1MEN1KMT2AUSP2 | |
| SCHEMBL6694565 | 0.76 | TSHR (0.50) | TSHRMAPK1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |