Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294793 | 0.87 | TSHR (0.44) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL7777354 | 0.86 | TSHR (0.33) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL7777477 | 0.86 | BLM (0.39) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL7771245 | 0.86 | BLM (0.39) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL12646242 | 0.85 | BLM (0.48) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL2593277 | 0.82 | TSHR (0.56) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL522377 | 0.82 | TSHR (0.56) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL389508 | 0.80 | MEN1 (0.58) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL19543545 | 0.80 | BLM (0.39) | BLMPMP22HSD17B10TSHRMAPK1 | |
| SCHEMBL7777480 | 0.78 | BLM (0.38) | BLMPMP22HSD17B10TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |