Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992050 | 0.87 | MAPT (0.59) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL10643488 | 0.86 | ALDH1A1 (0.64) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL12526290 | 0.84 | MAPT (0.63) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL3999404 | 0.84 | ALDH1A1 (0.76) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL2836012 | 0.84 | POLB (0.63) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL839776 | 0.82 | PTGS2 (0.83) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL595168 | 0.82 | TDP1 (0.54) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL9911322 | 0.82 | KMT2A (0.63) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL6602827 | 0.81 | ALDH1A1 (0.62) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL11431170 | 0.81 | PLA2G4B (0.68) | ALDH1A1POLBMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |