Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ASPH | Q12797 | 1/20 | 0.48 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16657371 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL4810409 | 0.84 | MEN1 (0.71) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL29744982 | 0.84 | MEN1 (0.71) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL11901159 | 0.80 | HTT (0.47) | ALDH1A1L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL11998916 | 0.80 | GSK3A (0.49) | ALDH1A1MAPK1TDP1MEN1KMT2A | |
| SCHEMBL10569621 | 0.79 | ALDH1A1 (0.74) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL16655995 | 0.78 | MAPT (0.47) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL16654895 | 0.78 | MAPT (0.55) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL28523405 | 0.78 | EPAS1 (0.52) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL27987003 | 0.78 | ALDH1A1 (0.78) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252594-B1 | 4-AMINO-5-FLUORO-PYRIMIDINE DERIVATIVES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2015-08-19 | — | — | EP | disclosed |
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0126254-B1 | N-(2-NITROPHENYL)-4-AMINOPYRIMIDINE DERIVATIVES AS MICROBICIDES | CIBA-GEIGY AG (CH) | 1987-11-11 | — | — | EP | disclosed |
| US-4705790-A | N-(2-nitrophenyl)-4-aminopyrimidine microbicides | CIBA-GEIGY CORPORATION (US) | 1987-11-10 | — | — | US | disclosed |
| US-4705790-A | N-(2-nitrophenyl)-4-aminopyrimidine microbicides | CIBA-GEIGY CORPORATION (US) | 1987-11-10 | — | — | US | disclosed |
| US-4705790-A | N-(2-nitrophenyl)-4-aminopyrimidine microbicides | CIBA-GEIGY CORPORATION (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0139613-A1 | N-(2-nitrophenyl)-4-aminopyrimidine derivatives, their preparation and use | CIBA-GEIGY AG (CH) | 1985-05-02 | — | — | EP | disclosed |
| EP-0139613-A1 | N-(2-nitrophenyl)-4-aminopyrimidine derivatives, their preparation and use | CIBA-GEIGY AG (CH) | 1985-05-02 | — | — | EP | disclosed |
| EP-0126254-A1 | N-(2-nitrophenyl)-4-aminopyrimidine derivatives as microbicides | CIBA-GEIGY AG (CH) | 1984-11-28 | — | — | EP | disclosed |