Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234659 | 0.89 | ESR1 (0.52) | PLA2G4BPLA2G4APLA2G2ACYP3A4HIF1A | |
| SCHEMBL155779 | 0.87 | MAOA (0.59) | MAOAMAOBCYP3A4HIF1ACYP1A2 | |
| SCHEMBL3234118 | 0.83 | ESR1 (0.52) | CYP3A4HIF1ACYP2C19ESR1ADRA2A | |
| SCHEMBL10699634 | 0.83 | LMNA (0.54) | CYP3A4HIF1AKDM4EALDH1A1LMNA | |
| SCHEMBL10698165 | 0.83 | LMNA (0.54) | CYP3A4HIF1AKDM4EALDH1A1LMNA | |
| SCHEMBL3892140 | 0.83 | MAOB (0.63) | PLA2G4BPLA2G4APLA2G2AMAOAMAOB | |
| SCHEMBL6564283 | 0.82 | CYP1A2 (0.61) | MAOAMAOBCYP3A4HIF1ACYP1A2 | |
| SCHEMBL9813820 | 0.81 | IGF1R (0.49) | CYP3A4HIF1ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5534675 | 0.81 | ESR1 (0.65) | DPP4MAOBTRPV1CYP3A4HIF1A | |
| SCHEMBL1841357 | 0.81 | ESR1 (0.65) | DPP4MAOBTRPV1CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |