Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 15/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070541 | 0.85 | MTNR1A (0.51) | ALOX15ADRB3ADRB1ADRA1ASMN1; SMN2 | |
| SCHEMBL6905931 | 0.84 | ALOX15 (0.54) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| SCHEMBL6912318 | 0.84 | ALOX15 (0.54) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| SCHEMBL6912018 | 0.84 | ALOX15 (0.54) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7111563 | 0.83 | ALOX15 (0.56) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7113305 | 0.83 | ALOX15 (0.56) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7108157 | 0.83 | ALOX15 (0.56) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| SCHEMBL7072936 | 0.82 | ALOX15 (0.48) | ALOX15ADRB3ADRB1ADRA1AALDH1A1 | |
| SCHEMBL6914729 | 0.77 | ALOX15 (0.46) | ALOX15ADRB3ADRB1ADRA1AKDM4E | |
| SCHEMBL7108272 | 0.77 | ALOX15 (0.46) | ALOX15ADRB3ADRB1ADRA1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128845-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTDIABETIC AGENT | SMITHKLINE BEECHAM PLC (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027434-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTIDIABETIC AGENT | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-18 | — | — | WO | disclosed |