Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.58 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 2/20 | 0.51 |
| ▸ | WDR5 | P61964 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782251 | 0.93 | MAPK14 (0.66) | MAPK14HPGDSSMOGLSABL1 | |
| SCHEMBL2972329 | 0.92 | MAPK14 (0.61) | MAPK14HPGDSSMOGLSBRAF | |
| SCHEMBL3262849 | 0.90 | MAPK14 (0.58) | MAPK14HPGDSSMOGLSBRAF | |
| SCHEMBL27581172 | 0.89 | MAPK14 (0.58) | MAPK14HPGDSSMOABL1KCNH2 | |
| SCHEMBL7846789 | 0.88 | MAPK14 (0.55) | MAPK14HPGDSGLS | |
| SCHEMBL7611262 | 0.87 | HPGDS (0.68) | MAPK14HPGDSGLSBRAF | |
| SCHEMBL7780464 | 0.87 | MAPK14 (0.65) | MAPK14SMO | |
| SCHEMBL7855875 | 0.85 | MAPK14 (0.52) | MAPK14GLSBRAF | |
| SCHEMBL7606215 | 0.84 | HPGDS (0.60) | MAPK14HPGDSABL1BRAF | |
| SCHEMBL7809438 | 0.83 | MAPK14 (0.59) | MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001517620-A | — | — | 2001-10-09 | — | — | JP | claimed |
| EP-1017378-A1 | AMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca UK Limited (GB) | 2000-07-12 | — | — | EP | claimed |
| WO-1999015164-A1 | AMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ZENECA LIMITED (GB) | 1999-04-01 | — | — | WO | claimed |
| EP-1017378-A1 | AMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca UK Limited (GB) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015164-A1 | AMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ZENECA LIMITED (GB) | 1999-04-01 | — | — | WO | disclosed |