Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | GLS | O94925 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.51 |
| ▸ | LDLR | P01130 | 1/20 | 0.51 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855875 | 0.97 | MAPK14 (0.52) | MAPK14HTR1DHTR1BHTR2AGLS | |
| SCHEMBL2972329 | 0.92 | MAPK14 (0.61) | MAPK14HTR1DHTR1BHTR2AGLS | |
| SCHEMBL3262849 | 0.90 | MAPK14 (0.58) | MAPK14HTR1DHTR1BHTR2AGLS | |
| SCHEMBL7779426 | 0.88 | MAPK14 (0.58) | MAPK14GLSHPGDS | |
| SCHEMBL7856635 | 0.87 | MAPK14 (0.57) | MAPK14 | |
| SCHEMBL6782251 | 0.86 | MAPK14 (0.66) | MAPK14GLSKITHPGDS | |
| SCHEMBL27581172 | 0.85 | MAPK14 (0.58) | MAPK14KITLMNAHPGDS | |
| SCHEMBL7855408 | 0.85 | MAPK14 (0.64) | MAPK14KITDDR1 | |
| SCHEMBL7846779 | 0.83 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL7835224 | 0.81 | LMNA (0.50) | MAPK14HTR2AKITDDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | claimed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | claimed |
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |