Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8395086 | 1.00 | SIGMAR1 (0.39) | SIGMAR1HRH4HRH3EPHX1NPC1 | |
| Hydrochloric Acid SCHEMBL7784622 | 0.99 | SIGMAR1 (0.38) | SIGMAR1HRH4HRH3EPHX1NPC1 | |
| Hydrochloric Acid SCHEMBL8476932 | 0.99 | SIGMAR1 (0.38) | SIGMAR1HRH4HRH3EPHX1NPC1 | |
| Hydrochloric Acid SCHEMBL7784625 | 0.99 | SIGMAR1 (0.38) | SIGMAR1HRH4HRH3EPHX1NPC1 | |
| Maleic Acid SCHEMBL8398515 | 0.94 | HRH4 (0.43) | SIGMAR1HRH4HRH3EPHX1NPC1 | |
| Fumaric Acid SCHEMBL7779684 | 0.94 | HRH4 (0.43) | SIGMAR1HRH4HRH3EPHX1NPC1 | |
| SCHEMBL7787710 | 0.93 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3RAB9AMEN1 | |
| SCHEMBL7779566 | 0.93 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3RAB9AMEN1 | |
| SCHEMBL7779569 | 0.93 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3RAB9AMEN1 | |
| SCHEMBL7786425 | 0.92 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |