Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7779566 | 1.00 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3NAMPTKDM1A | |
| SCHEMBL7779569 | 1.00 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3NAMPTKDM1A | |
| SCHEMBL7779650 | 0.97 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3NAMPTADAMTS4 | |
| SCHEMBL7786425 | 0.97 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3NAMPTADAMTS4 | |
| SCHEMBL7779653 | 0.97 | SIGMAR1 (0.42) | SIGMAR1HRH4HRH3NAMPTADAMTS4 | |
| SCHEMBL8395086 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HRH4HRH3MEN1RAB9A | |
| SCHEMBL7779583 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HRH4HRH3MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL7784622 | 0.92 | SIGMAR1 (0.38) | SIGMAR1HRH4HRH3MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL8476932 | 0.92 | SIGMAR1 (0.38) | SIGMAR1HRH4HRH3MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL7784625 | 0.92 | SIGMAR1 (0.38) | SIGMAR1HRH4HRH3MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |