Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7773203 | 0.91 | PTGS2 (0.49) | PTGS2PTGS1CYP2C9KIF11 | |
| SCHEMBL7780870 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1ABCB11 | |
| SCHEMBL7773256 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1PDPK1PTGESHDAC3 | |
| SCHEMBL7780060 | 0.86 | PTGS2 (0.66) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL7777684 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL8628757 | 0.85 | F10 (0.38) | PTGS2PTGS1 | |
| SCHEMBL7772816 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1PDPK1PTGESHDAC3 | |
| SCHEMBL7780102 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1PDPK1CA12MT-CO2 | |
| SCHEMBL7777338 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1PDPK1PTGESHDAC3 | |
| SCHEMBL7773180 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1PDPK1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772597-B1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1127878-A1 | 3,4 - substituted pyrazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6028072-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |
| US-5580985-A | ANTIARTHRITIC AGENT; SIDE EFFECT REDUCTION | G. D. SEARLE & CO. (US) | 1996-12-03 | — | — | US | disclosed |