Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.79 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.79 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.79 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.79 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.79 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.79 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.79 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | IDE | P14735 | 1/20 | 0.50 |
| ▸ | MPI | P34949 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29495630 | 0.89 | KDM4E (1.00) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL239920 | 0.89 | KDM4E (1.00) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8873559 | 0.78 | KDM4E (0.78) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| Carbazole SCHEMBL8411559 | 0.74 | ALDH1A1 (0.74) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2805779 | 0.72 | KDM4E (1.00) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29415434 | 0.72 | KDM4E (1.00) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8873438 | 0.72 | PARP1 (0.74) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8871845 | 0.72 | KDM4E (0.58) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8871843 | 0.72 | KDM4E (0.58) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4558727 | 0.71 | KDM4E (0.67) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251903-B1 | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist | COCENSYS, INC. | 2001-06-26 | — | — | US | disclosed |
| US-6147075-A | ANALGESICS; PSYCHOLOGICAL DISORDERS | COCENSYS, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0732942-A4 | ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS | COCENSYS INC (US) | 2000-03-22 | — | — | EP | disclosed |
| US-5977107-A | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonists | COCENSYS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5631373-A | NERVOUS SYSTEM DISORDERS | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0732942-A1 | ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS | ACEA PHARMACEUTICALS, INC. (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995012417-A1 | ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS | ACEA PHARMACEUTICALS, INC. (US) | 1995-05-11 | — | — | WO | disclosed |