Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13209092 | 0.81 | ALDH1A1 (0.58) | ALDH1A1XBP1HTTMAOAMAOB | |
| Hydrochloric Acid SCHEMBL7328177 | 0.80 | HTT (0.53) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL7550905 | 0.79 | SIGMAR1 (0.41) | SIGMAR1HRH3 | |
| SCHEMBL12124859 | 0.78 | HTT (0.57) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL12124861 | 0.78 | HTT (0.57) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL12124857 | 0.78 | HTT (0.57) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL7505642 | 0.78 | HRH3 (0.41) | SIGMAR1HRH3 | |
| SCHEMBL14528375 | 0.78 | ALDH1A1 (0.51) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL13209098 | 0.78 | ALDH1A1 (0.51) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL13034225 | 0.76 | ALDH1A1 (0.47) | ALDH1A1XBP1HTTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140852-A1 | 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARAMACEUTICAL USE | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035882-A1 | 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2000-06-22 | — | — | WO | claimed |