Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.59 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7779193 | 0.89 | PLA2G4B (0.53) | PLA2G4BPLA2G4APLA2G2AMAPTMEN1 | |
| SCHEMBL7782197 | 0.89 | PLA2G4A (0.66) | PLA2G4BPLA2G4APLA2G2ASMN1; SMN2MAPT | |
| SCHEMBL7782754 | 0.84 | SMN1; SMN2 (0.50) | PLA2G4ASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7780140 | 0.83 | PLA2G4B (0.58) | PLA2G4BPLA2G4APLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL17363389 | 0.83 | PLA2G4A (0.61) | PLA2G4ASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7782090 | 0.82 | PLA2G4B (0.54) | PLA2G4BPLA2G4APLA2G2AMEN1KMT2A | |
| SCHEMBL7780170 | 0.81 | PLA2G4B (0.53) | PLA2G4BPLA2G4APLA2G2APPARGPPARA | |
| SCHEMBL7781878 | 0.81 | PLA2G4B (0.52) | PLA2G4BPLA2G4APLA2G2AMAPTPPARD | |
| SCHEMBL7780095 | 0.79 | MAPT (0.48) | PLA2G4BPLA2G4APLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL7782746 | 0.79 | PLA2G4B (0.76) | PLA2G4BPLA2G4APLA2G2ANPC1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | claimed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | claimed |
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |