Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.76 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.76 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.73 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747055 | 0.84 | FFAR1 (0.74) | PLA2G4BPLA2G2AFFAR1S1PR1S1PR3 | |
| SCHEMBL7775041 | 0.83 | PLA2G4B (0.64) | PLA2G4BPLA2G4APLA2G2AFFAR1S1PR1 | |
| SCHEMBL7782117 | 0.81 | PLA2G4B (0.61) | PLA2G4BPLA2G4APLA2G2AFFAR1S1PR1 | |
| SCHEMBL1744514 | 0.81 | FFAR1 (0.65) | PLA2G4BPLA2G4APLA2G2AFFAR1S1PR1 | |
| SCHEMBL4266126 | 0.80 | ALDH1A1 (0.59) | PLA2G4BPLA2G4APLA2G2AALOX15MAPT | |
| SCHEMBL7782763 | 0.79 | PLA2G4B (0.59) | PLA2G4BPLA2G4APLA2G2AFFAR1S1PR1 | |
| SCHEMBL7780092 | 0.79 | PLA2G4B (0.59) | PLA2G4BPLA2G4APLA2G2APPARGPPARA | |
| SCHEMBL7774959 | 0.78 | PLA2G4B (0.58) | PLA2G4BPLA2G4APLA2G2AFFAR1S1PR1 | |
| SCHEMBL28669666 | 0.77 | ALOX15 (0.70) | FFAR1PPARGPPARAALOX15MAPT | |
| SCHEMBL7779176 | 0.76 | PLA2G4B (0.54) | PLA2G4BPLA2G4APLA2G2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |