Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 5/20 | 0.49 |
| ▸ | S100A4 | P26447 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296661 | 0.85 | CASP3 (0.62) | CES1TTRCASP3S100A4CASP1 | |
| SCHEMBL30704875 | 0.85 | CASP3 (0.62) | CES1TTRCASP3S100A4CASP1 | |
| SCHEMBL19657305 | 0.78 | TTR (0.57) | CES1TTRCASP3CASP1CASP4 | |
| SCHEMBL5190489 | 0.78 | CA2 (0.44) | TTRAPAF1S100A4CA2CA1 | |
| SCHEMBL5190480 | 0.78 | CA2 (0.44) | TTRAPAF1S100A4CA2CA1 | |
| SCHEMBL20535085 | 0.78 | CA2 (0.36) | APAF1CASP3S100A4CA2CA1 | |
| SCHEMBL30404664 | 0.77 | TTR (0.55) | CES1TTRCASP3CASP1CASP4 | |
| SCHEMBL29704375 | 0.77 | CES1 (0.55) | CES1TTRCASP3S100A4CASP1 | |
| SCHEMBL15094827 | 0.77 | TTR (0.55) | CES1TTRCASP3CASP1CASP4 | |
| SCHEMBL19657758 | 0.77 | CES1 (0.55) | CES1TTRCASP3CASP1CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113735871-B | Preparation method and application of indole spiro dihydropyridine dicoumarol compound | 江苏大学 | 2023-04-11 | — | — | CN | disclosed |
| CN-112898311-B | Indole spiro pyridocoumarin compound and preparation method and application thereof | 江苏大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-113735871-A | Preparation method and application of indole spiro dihydropyridine dicoumarol compound | 江苏大学 | 2021-12-03 | — | — | CN | disclosed |
| CN-113564623-A | Method for preparing isatin compound by electrochemically oxidizing N-substituted indole derivative | 福建师范大学 | 2021-10-29 | — | — | CN | disclosed |
| CN-112898311-A | Indole spiro pyridocoumarin compound and preparation method and application thereof | 江苏大学 | 2021-06-04 | — | — | CN | disclosed |
| US-20210130346-A1 | Bromodomain Inhibitors | ABBVIE INC. (US) | 2021-05-06 | — | — | US | disclosed |
| EP-3609896-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018188047-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| CN-104557957-B | Synthetic method of spiro-oxoindole ethylene oxide derivative | 华东师范大学 | 2017-04-19 | — | — | CN | disclosed |
| EP-1135123-A1 | USE OF ISATIN DERIVATIVES AS ION CHANNEL ACTIVATING AGENTS | NEUROSEARCH A/S (DK) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000033834-A1 | USE OF ISATIN DERIVATIVES AS ION CHANNEL ACTIVATING AGENTS | NEUROSEARCH A/S (DK) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130346-A1 | Bromodomain Inhibitors | BRD4, BRD1, BRD3 | CES1 577/4885TTR 4569/4885APAF1 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.