Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787458 | 0.92 | LMNA (0.45) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7780564 | 0.87 | MAPK1 (0.46) | MEN1KMT2ASMN1; SMN2NPC1GAA | |
| SCHEMBL7785152 | 0.87 | MAPK1 (0.46) | MEN1KMT2ASMN1; SMN2NPC1GAA | |
| SCHEMBL7785701 | 0.86 | LMNA (0.39) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7787532 | 0.85 | MEN1 (0.40) | MEN1KMT2ASMN1; SMN2NPC1GAA | |
| SCHEMBL27533527 | 0.85 | MEN1 (0.40) | MEN1KMT2ASMN1; SMN2NPC1GAA | |
| SCHEMBL7785105 | 0.84 | CRHBP (0.44) | MEN1KMT2ASMN1; SMN2GAALMNA | |
| SCHEMBL7785576 | 0.84 | CRHBP (0.44) | MEN1KMT2ASMN1; SMN2GAALMNA | |
| SCHEMBL27540162 | 0.83 | HTT (0.46) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL7780592 | 0.83 | HTT (0.46) | MEN1KMT2ASMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |