SCHEMBL778048

SCHEMBL778048

COc1ccc2sc(S)nc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.54
RAB9A P51151 6/20 0.54
SMN1; SMN2 Q16637 5/20 0.54
DYRK1A Q13627 3/20 0.54
PPARA Q07869 4/20 0.49
ILK Q13418 1/20 0.48
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C19 P33261 1/20 0.47
ALDH1A1 P00352 2/20 0.47
TP53 P04637 2/20 0.47
ALOX15 P16050 1/20 0.47
MAPK1 P28482 1/20 0.47
PDK1 Q15118 1/20 0.46
BACE1 P56817 1/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.46
NQO2 P16083 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30627231 1.00 NPC1 (0.54) NPC1RAB9ASMN1; SMN2DYRK1APPARA
SCHEMBL9157816 0.88 PPARA (0.53) NPC1RAB9ASMN1; SMN2DYRK1APPARA
SCHEMBL5923359 0.86 CYP1A2 (0.65) NPC1RAB9ASMN1; SMN2DYRK1ACYP1A2
2-Mercaptobenzothiazole SCHEMBL2172823 0.85 PDE10A (0.49) NPC1RAB9ASMN1; SMN2DYRK1AILK
Methane SCHEMBL2171653 0.85 PDE10A (0.49) NPC1RAB9ASMN1; SMN2DYRK1AILK
SCHEMBL6692946 0.81 KMT2A (0.51) NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4
SCHEMBL31276816 0.80 NPC1 (0.55) NPC1RAB9ASMN1; SMN2DYRK1APPARA
SCHEMBL2400142 0.80 NPC1 (0.55) NPC1RAB9ASMN1; SMN2DYRK1APPARA
SCHEMBL95067 0.80 NPC1 (0.55) NPC1RAB9ASMN1; SMN2DYRK1APPARA
SCHEMBL6690420 0.79 ATP4A (0.44) NPC1RAB9ASMN1; SMN2CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 476 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12575418-B2 Semiconductor packages having organic material layer between through-via structure and encapsulant that surrounds a portion of semiconductor chip SAMSUNG ELECTRONICS CO., LTD. (KR) 2026-03-10 US claimed
US-20240006342-A1 SEMICONDUCTOR PACKAGES SAMSUNG ELECTRONICS CO., LTD. (KR) 2024-01-04 US claimed
CN-117286499-A Copper etching solution 福建钰融科技有限公司 2023-12-26 CN claimed
CN-113754650-B High-selectivity synthesis method of rosuvastatin calcium intermediate 湖北宇阳药业有限公司 2023-10-20 CN claimed
CN-116623186-A Corrosion inhibitor for inhibiting electrochemical corrosion and preparation method thereof 范斌磊 2023-08-22 CN claimed
CN-113754650-A High-selectivity synthesis method of rosuvastatin calcium intermediate 湖北宇阳药业有限公司 2021-12-07 CN claimed
CN-113045993-A Polishing solution for processing ultra-smooth low-damage bearing steel surface and application thereof 西南交通大学 2021-06-29 CN claimed
US-20040018983-A1 Antifungal compositions ACHILLION PHARMACEUTICALS, INC. 2004-01-29 US claimed
WO-2003055448-A2 ANTIFUNGAL COMPOSITIONS ACHILLION PHARMACEUTICALS, INC. (US) 2003-07-10 WO claimed
US-12575418-B2 Semiconductor packages having organic material layer between through-via structure and encapsulant that surrounds a portion of semiconductor chip SAMSUNG ELECTRONICS CO., LTD. (KR) 2026-03-10 US disclosed
CN-117677675-B Halogenated phthalocyanine color material, colored curable composition, color filter, and display device DNP精细化工股份有限公司 2026-02-27 CN disclosed
US-20260022122-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME CHECKMATE THERAPEUTICS INC. (KR) 2026-01-22 US disclosed
US-20250333417-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-10-30 US disclosed
US-12422749-B2 Photosensitive ink composition, cured product, display panel, and method for producing cured product TOKYO OHKA KOGYO CO., LTD. (JP) 2025-09-23 US disclosed
EP-0430115-A1 Radiographic elements with improved covering power E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-06-05 EP disclosed
EP-0129506-B1 HETEROCYCLICALLY SUBSTITUTED THIO(CYCLO)ALKANE POLYCARBOXYLIC ACIDS CIBA-GEIGY AG (CH) 1991-03-06 EP disclosed
US-4740596-A Process for preparation of 4-sulfonylthio azetidinone derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1988-04-26 US disclosed
US-4713452-A Process for preparation of azetidinone derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1987-12-15 US disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed
US-4454148-A 5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure MERCK & CO., INC. (US) 1984-06-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040018983-A1 Antifungal compositions CNBP, ERG28, AEBP2 NPC1 1211/4885RAB9A 4220/4885SMN1; SMN2 4019/4885
US-20250333417-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 NPC1 3159/4885RAB9A 4270/4885SMN1; SMN2 2647/4885
US-12575418-B2 Semiconductor packages having organic material layer between through-via structure and encapsulant that surrounds a portion of semiconductor chip MTAP, TPMT, PIM2 NPC1 4430/4885RAB9A 4249/4885SMN1; SMN2 2437/4885
US-20260022122-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME NAMPT, NAPRT, NNT NPC1 57/4885RAB9A 1585/4885SMN1; SMN2 2571/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.