Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780505 | 0.83 | RPS6KB1 (0.48) | — | |
| SCHEMBL7778364 | 0.82 | CREBBP (0.49) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL6016697 | 0.81 | LMNA (0.66) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL6016698 | 0.81 | LMNA (0.66) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL7778558 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL7773692 | 0.78 | LMNA (0.65) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL7778556 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL27881279 | 0.75 | LMNA (1.00) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL7781149 | 0.75 | LMNA (0.63) | SMN1; SMN2HSD17B10LMNABRD4TSHR | |
| SCHEMBL7780684 | 0.72 | EGFR (0.62) | LMNAHDAC11HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853616-B1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-19 | — | — | EP | claimed |
| CN-1198158-A | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1998-11-04 | — | — | CN | claimed |
| EP-0853616-A1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-07-22 | — | — | EP | claimed |
| WO-1997049689-A1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-31 | — | — | WO | claimed |
| EP-0853616-B1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-19 | — | — | EP | disclosed |
| US-6057326-A | USED FOR TREATING EPIDERMAL HYPERPROLIFERATION, AS AN ANTI-METASTATIC OR ANTI-CANCER AGENT, TO CONTROL ANGIOGENESIS, INHIBIT DEVELOPMENT OF ATHEROMATOUS PLAQUE, TREATING ALZHEIMER'S DISEASE, OR AS AN IMMUNOMODULATING AGENT | PHARMACIA & UPJOHN S.P.A (IT) | 2000-05-02 | — | — | US | disclosed |
| CN-1198158-A | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1998-11-04 | — | — | CN | disclosed |
| EP-0853616-A1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997049689-A1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-31 | — | — | WO | disclosed |