Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | BRD4 | O60885 | 8/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781149 | 0.85 | LMNA (0.63) | SMN1; SMN2HSD17B10LMNABRD4NT5C2 | |
| SCHEMBL7778551 | 0.82 | EGFR (0.52) | SMN1; SMN2HSD17B10LMNAEGFR | |
| SCHEMBL7780508 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2HSD17B10LMNABRD4NT5C2 | |
| SCHEMBL27881279 | 0.78 | LMNA (1.00) | SMN1; SMN2HSD17B10LMNABRD4EGFR | |
| SCHEMBL7778517 | 0.75 | LMNA (0.66) | SMN1; SMN2HSD17B10LMNABRD4NT5C2 | |
| SCHEMBL6016698 | 0.75 | LMNA (0.66) | SMN1; SMN2HSD17B10LMNABRD4EGFR | |
| SCHEMBL6016697 | 0.75 | LMNA (0.66) | SMN1; SMN2HSD17B10LMNABRD4EGFR | |
| SCHEMBL28900810 | 0.75 | BRD4 (0.62) | SMN1; SMN2HSD17B10LMNABRD4NT5C2 | |
| SCHEMBL6753015 | 0.72 | BRD4 (0.62) | HSD17B10LMNABRD4NT5C2CREBBP | |
| SCHEMBL4496035 | 0.72 | SMN1; SMN2 (0.70) | SMN1; SMN2HSD17B10LMNABRD4NT5C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853616-B1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-19 | — | — | EP | claimed |
| CN-1198158-A | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1998-11-04 | — | — | CN | claimed |
| EP-0853616-B1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-19 | — | — | EP | disclosed |
| US-6057326-A | USED FOR TREATING EPIDERMAL HYPERPROLIFERATION, AS AN ANTI-METASTATIC OR ANTI-CANCER AGENT, TO CONTROL ANGIOGENESIS, INHIBIT DEVELOPMENT OF ATHEROMATOUS PLAQUE, TREATING ALZHEIMER'S DISEASE, OR AS AN IMMUNOMODULATING AGENT | PHARMACIA & UPJOHN S.P.A (IT) | 2000-05-02 | — | — | US | disclosed |
| CN-1198158-A | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1998-11-04 | — | — | CN | disclosed |
| EP-0853616-A1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997049689-A1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-31 | — | — | WO | disclosed |