Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | MARK3 | P27448 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787503 | 0.94 | POLB (0.33) | MAPKAPK2POLB | |
| SCHEMBL7780084 | 0.89 | MAPKAPK2 (0.38) | MAPKAPK2POLBROCK2CDK1RPS6KB1 | |
| SCHEMBL7780535 | 0.88 | POLB (0.35) | MAPKAPK2POLBPLK1MAPK14 | |
| SCHEMBL7780353 | 0.86 | POLB (0.34) | MAPKAPK2POLBCSF1RPLK4CHEK1 | |
| SCHEMBL7801984 | 0.86 | CXCR2 (0.36) | MAPKAPK2POLBCSF1RMAPK1 | |
| SCHEMBL7787795 | 0.84 | MAPKAPK2 (0.36) | MAPKAPK2POLBMAPK14 | |
| SCHEMBL7787734 | 0.84 | MAPKAPK2 (0.36) | MAPKAPK2POLBMAPK14 | |
| SCHEMBL7780384 | 0.83 | CXCR2 (0.33) | MAPKAPK2 | |
| SCHEMBL7789041 | 0.81 | KMT2A (0.36) | MAPKAPK2POLBMAPK1MAPK14 | |
| SCHEMBL7780305 | 0.80 | KMT2A (0.38) | MAPKAPK2POLBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |