Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787503 | 0.92 | POLB (0.33) | MAPKAPK2KMT2AMEN1POLBHTT | |
| SCHEMBL7780518 | 0.89 | MAPKAPK2 (0.34) | MAPKAPK2POLBMAPK1ROCK1CDK1 | |
| SCHEMBL7789041 | 0.89 | KMT2A (0.36) | MAPKAPK2KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL7801958 | 0.87 | MEN1 (0.39) | MAPKAPK2KMT2AMEN1POLBKCNB1 | |
| SCHEMBL7780535 | 0.86 | POLB (0.35) | MAPKAPK2KMT2AMEN1POLBHTT | |
| SCHEMBL7785270 | 0.85 | KMT2A (0.38) | MAPKAPK2KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL7787653 | 0.85 | KMT2A (0.38) | MAPKAPK2KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL7780305 | 0.85 | KMT2A (0.38) | MAPKAPK2KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL7780353 | 0.83 | POLB (0.34) | MAPKAPK2KMT2AMEN1POLBLMNA | |
| SCHEMBL7784990 | 0.81 | POLB (0.46) | MAPKAPK2KMT2AMEN1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |