Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 12/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7789355 | 0.91 | MAPKAPK2 (0.46) | MAPKAPK2MAPK14TDO2IDO1MAPK1 | |
| SCHEMBL7785589 | 0.91 | MAPKAPK2 (0.45) | MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL7787770 | 0.90 | KMT2A (0.40) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| SCHEMBL7785696 | 0.90 | KMT2A (0.40) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| SCHEMBL7785675 | 0.90 | KMT2A (0.40) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| SCHEMBL7780621 | 0.90 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL7787718 | 0.89 | KMT2A (0.40) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| SCHEMBL7780735 | 0.88 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| SCHEMBL7789434 | 0.88 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14MEN1POLBKMT2A | |
| SCHEMBL7787623 | 0.88 | CA1 (0.37) | MAPKAPK2MAPK14MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | claimed |
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |