Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 16/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | NEK4 | P51957 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780728 | 0.91 | MAPKAPK2 (0.37) | MAPKAPK2TDO2MAPK1IDO1MAPK14 | |
| SCHEMBL7787665 | 0.88 | MAPKAPK2 (0.51) | MAPKAPK2ROCK1AURKBDCLK1ROCK2 | |
| SCHEMBL7780308 | 0.88 | MAPKAPK2 (0.51) | MAPKAPK2ROCK1AURKBDCLK1ROCK2 | |
| SCHEMBL7788955 | 0.88 | MAPKAPK2 (0.51) | MAPKAPK2ROCK1AURKBDCLK1ROCK2 | |
| SCHEMBL7785696 | 0.88 | KMT2A (0.40) | MAPKAPK2TDO2MAPK14 | |
| SCHEMBL7787770 | 0.88 | KMT2A (0.40) | MAPKAPK2TDO2MAPK14 | |
| Hydrochloric Acid SCHEMBL7780333 | 0.88 | MAPKAPK2 (0.46) | MAPKAPK2TDO2ROCK1AURKBDCLK1 | |
| SCHEMBL7785675 | 0.88 | KMT2A (0.40) | MAPKAPK2TDO2MAPK14 | |
| Hydrochloric Acid SCHEMBL7787718 | 0.87 | KMT2A (0.40) | MAPKAPK2TDO2MAPK14 | |
| SCHEMBL7787623 | 0.85 | CA1 (0.37) | MAPKAPK2AURKBIDO1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |