Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 1/20 | 0.46 |
| ▸ | TK1 | P04183 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20494292 | 0.89 | TK1 (0.47) | TK2TK1LMNABLMTSHR | |
| SCHEMBL8611899 | 0.87 | TK2 (0.51) | TK2TK1LMNAALBBLM | |
| SCHEMBL2056644 | 0.85 | LMNA (0.51) | TK1LMNAALBBLMALDH1A1 | |
| SCHEMBL30449834 | 0.83 | TYMP (0.49) | TK1LMNAALBBLMALDH1A1 | |
| SCHEMBL6832174 | 0.83 | TK1 (0.51) | TK1LMNAALBBLMALDH1A1 | |
| SCHEMBL18670761 | 0.83 | SLC28A1 (0.40) | — | |
| SCHEMBL7780995 | 0.83 | TK1 (0.45) | TK2TK1LMNAALBBLM | |
| SCHEMBL6827395 | 0.82 | TK1 (0.45) | TK1LMNAALBBLMALDH1A1 | |
| SCHEMBL6224634 | 0.81 | TK1 (0.53) | TK1LMNAALBBLMALDH1A1 | |
| SCHEMBL6831326 | 0.81 | TK1 (0.47) | TK1LMNAALBBLMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707591-B1 | METHYLPHOSPHONIC ACID ESTER, PROCESS FOR PREPARING THE SAME AND ITS USE | AVENTIS PHARMA GMBH (DE) | 2001-09-26 | — | — | EP | disclosed |
| US-6028182-A | Methylphosphonic acid esters, processes for their preparation, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-22 | — | — | US | disclosed |
| US-5932718-A | CONTACTING NUCLEOTIDE OR OLIGONUCLEOTIDE HAVING 5' H-PHOSPHONATE DERIVATIVE WITH 5'-O-TRITYL-3'-AMINO-2'-DEOXYRIBONUCLEOSIDE IN PRESENCE OF OXIDIZING AGENT PRODUCING PROTECTED INTERNUCLEOSIDE LINKAGE | NORTHWESTERN UNIVERSITY (US) | 1999-08-03 | — | — | US | disclosed |
| US-5648480-A | Process for making oligonucleotides having modified internucleoside linkages | NORTHWESTERN UNIVERSITY (US) | 1997-07-15 | — | — | US | disclosed |
| US-5646260-A | PHOSPHORYLATED OLIGONUCLEOTIDES | LETSINGER ROBERT L (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0707591-A1 | METHYLPHOSPHONIC ACID ESTER, PROCESS FOR PREPARING THE SAME AND ITS USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-24 | — | — | EP | disclosed |
| US-5476925-A | Antisense agents | NORTHWESTERN UNIVERSITY (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1995001363-A1 | METHYLPHOSPHONIC ACID ESTER, PROCESS FOR PREPARING THE SAME AND ITS USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-01-12 | — | — | WO | disclosed |
| US-4973679-A | Process for oligonucleo tide synthesis using phosphormidite intermediates | UNIVERSITY PATENTS, INC. (US) | 1990-11-27 | — | — | US | disclosed |
| US-4668777-A | POLYNUCLEOTIDE INTERMEDIATES | UNIVERSITY PATENTS, INC. (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0061746-B1 | PHOSPHORAMIDITE COMPOUNDS AND THEIR USE IN PRODUCING OLIGONUCLEOTIDES | UNIVERSITY PATENTS, INC. (US) | 1985-03-20 | — | — | EP | disclosed |
| US-4415732-A | STORAGE-STABLE NUCLEOSIDES; POLYNUCLEOTIDE SYNTHESIS | UNIVERSITY PATENTS, INC. (US) | 1983-11-15 | — | — | US | disclosed |
| EP-0061746-A1 | Phosphoramidite compounds and their use in producing oligonucleotides | UNIVERSITY PATENTS, INC. (US) | 1982-10-06 | — | — | EP | disclosed |