Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.72 |
| ▸ | MAOA | P21397 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.72 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.65 |
| ▸ | BACE1 | P56817 | 2/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.62 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806449 | 0.86 | CYP3A4 (0.71) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| Methoxsalen SCHEMBL29376525 | 0.84 | CYP3A4 (1.00) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| Methoxsalen SCHEMBL19168 | 0.84 | CYP3A4 (1.00) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| Methoxsalen SCHEMBL2302069 | 0.84 | CYP3A4 (1.00) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| SCHEMBL9184365 | 0.83 | MAOA (0.76) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| Methoxsalen SCHEMBL6142553 | 0.82 | CYP3A4 (0.97) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| SCHEMBL18788617 | 0.82 | MAOA (0.78) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| SCHEMBL18788581 | 0.82 | CA9 (0.70) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| SCHEMBL13920857 | 0.82 | MAOA (0.69) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 | |
| SCHEMBL4262282 | 0.82 | CYP3A4 (0.65) | CYP3A4MAOACYP1A2CYP2D6CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236503-B1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORP (TW) | 2014-02-26 | — | — | EP | disclosed |
| US-8318801-B2 | Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2012-11-27 | — | — | US | disclosed |
| US-8318801-B2 | Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2012-11-27 | — | — | US | disclosed |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-09-15 | — | — | US | disclosed |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-09-15 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-7994357-B2 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2011-08-09 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) | 2010-10-07 | — | — | US | disclosed |
| EP-2236503-A1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NatureWise Biotech & Medicals Corporation (TW) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256401-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | CYP3A4 4539/4885MAOA 1639/4885CYP1A2 4213/4885 |
| US-20110224294-A1 | CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE | SMN1; SMN2, HDAC1, HDAC5 | CYP3A4 4539/4885MAOA 1639/4885CYP1A2 4213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.