Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.50 |
| ▸ | APEX1 | P27695 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL14856340 | 0.97 | CYP3A4 (0.65) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL136983 | 0.97 | MEN1 (0.63) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL9447035 | 0.95 | MEN1 (0.60) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL316335 | 0.95 | MEN1 (0.60) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL9447076 | 0.95 | MEN1 (0.60) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL28375564 | 0.95 | MEN1 (0.60) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL9447024 | 0.95 | MEN1 (0.60) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL7646161 | 0.92 | MEN1 (0.57) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL7646166 | 0.90 | CYP3A4 (0.62) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL28369650 | 0.90 | CYP3A4 (0.62) | CYP3A4SLC5A7MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057813-A | Method for synthesizing sodium citicoline | 新乡拓新药业股份有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-110684066-B | Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness | 广东金城金素制药有限公司 | 2020-12-08 | — | — | CN | claimed |
| CN-110684066-A | Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness | 广东金城金素制药有限公司 | 2020-01-14 | — | — | CN | claimed |
| US-5500668-A | INK JET PRINTING | XEROX CORPORATION (US) | 1996-03-19 | — | — | US | claimed |
| CN-114106043-A | Compound, preparation method thereof, method for preparing citicoline by compound and application | 成都海博为药业有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-114057813-A | Method for synthesizing sodium citicoline | 新乡拓新药业股份有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-113307823-A | Purification and desalination process in production of choline phosphate by electrodialysis method | 沈阳金久奇科技有限公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-110684066-B | Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness | 广东金城金素制药有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-110684066-B | Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness | 广东金城金素制药有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-110759942-A | Method for industrially producing choline alfoscerate | 江苏恒正合生命科学有限公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-110684066-A | Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness | 广东金城金素制药有限公司 | 2020-01-14 | — | — | CN | disclosed |
| CN-110684066-A | Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness | 广东金城金素制药有限公司 | 2020-01-14 | — | — | CN | disclosed |
| EP-0877559-A1 | CAT FOOD COMPOSITION OF IMPROVED PALATABILITY | Colgate-Palmolive Company (US) | 1998-11-18 | — | — | EP | disclosed |
| US-5690988-A | DRY CAT FOOD HAVING CHOLINE COMPOUND | COLGATE PALMOLIVE COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1997027762-A1 | CAT FOOD COMPOSITION OF IMPROVED PALATABILITY | COLGATE-PALMOLIVE COMPANY (US) | 1997-08-07 | — | — | WO | disclosed |
| EP-0730674-A1 | ANTICORROSION SYSTEM | Colgate-Palmolive Company (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5554320-A | ANTICORROSIVE SOLUTION OF PHOSPHORIC ACID AND QUATERNARY AMMONIUM SALT; PROTECTIVE COATING FOR ACID SENSITIVE ENAMELS | COLGATE-PALMOLIVE COMPANY | 1996-09-10 | — | — | US | disclosed |
| US-5500668-A | INK JET PRINTING | XEROX CORPORATION (US) | 1996-03-19 | — | — | US | disclosed |
| US-5462697-A | Aqueous cleaning compounds containing mixtures of nonionic, anionic and cationic surfactants, phosphoric acid and carboxylic acids | COLGATE-PALMOLIVE CO. (US) | 1995-10-31 | — | — | US | disclosed |
| WO-1995014795-A1 | ANTICORROSION SYSTEM | COLGATE-PALMOLIVE COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |