Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | APEX1 | P27695 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL136983 | 0.97 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9447035 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9447024 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9447076 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL7782023 | 0.95 | CYP3A4 (0.68) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL28375564 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL1934636 | 0.92 | LMNA (0.57) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL14856340 | 0.92 | CYP3A4 (0.65) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL7646161 | 0.92 | MEN1 (0.57) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15922003 | 0.90 | LMNA (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121203453-B | Multipurpose heat-resistant flame-retardant coating and preparation method thereof | 广州和新实业有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12551441-B2 | Water soluble silicon-containing granulate | BIO MINERALS NV (BE) | 2026-02-17 | — | — | US | claimed |
| EP-4512926-A1 | A PHOTONIC LAYER DOPED WITH NANOPARTICLES AND A METHOD FOR OBTAINING SAID PHOTONIC LAYER | Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii (PL) | 2025-02-26 | — | — | EP | claimed |
| CN-114621984-B | Method for synthesizing 1, 5-pentanediamine by using ionic liquid to strengthen lysine decarboxylase | 中国科学院过程工程研究所 | 2025-01-28 | — | — | CN | claimed |
| CN-112165951-B | Protein formulation additives for improving thermal stability | 默克专利股份有限公司 | 2024-12-13 | — | — | CN | claimed |
| US-20240408130-A1 | Combination of Silicon and Magnesium for the Prevention and Treatment of Muscle Cramps | BIO MINERALS N.V. (BE) | 2024-12-12 | — | — | US | claimed |
| US-20240398957-A1 | ADDITIVES FOR PROTEIN FORMULATIONS TO IMPROVE THERMAL STABILITY | MERCK PATENT GMBH (DE) | 2024-12-05 | — | — | US | claimed |
| CN-117800855-A | Preparation method of choline dihydrogen phosphate | 济南亚西亚药业有限公司 | 2024-04-02 | — | — | CN | claimed |
| US-11878031-B2 | Silicic acids for use in the treatment of periodontitis | BIO MINERALS N.V. (BE) | 2024-01-23 | — | — | US | claimed |
| US-11624116-B2 | Bioassisted treatment of microbiologically influenced corrosion in petroleum transporting pipelines | INDIAN OIL CORPORATION LIMITED (IN) | 2023-04-11 | — | — | US | claimed |
| EP-3632449-A1 | SILICIC ACIDS FOR USE IN THE TREATMENT OF PERIODONTITIS | Bio Minerals N.V. (BE) | 2020-04-08 | — | — | EP | claimed |
| WO-2019201894-A1 | ADDITIVES FOR PROTEIN FORMULATIONS TO IMPROVE THERMAL STABILITY | MERCK PATENT GMBH (DE) | 2019-10-24 | — | — | WO | claimed |
| US-20180192641-A1 | Compositions and Methods for Preservation of Materials in the Amorphous State | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-07-12 | — | — | US | claimed |
| US-9930883-B2 | Compositions and methods for preservation of materials in the amorphous state | UNIVERSITY OF NORTH CAROLLINA CHARLOTTE (US) | 2018-04-03 | — | — | US | claimed |
| US-20160165879-A1 | Compositions and Methods for Preservation of Materials in the Amorphous State | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | claimed |
| US-9289381-B2 | Stabilization and storage of biological pharmaceutical compositions | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2016-03-22 | — | — | US | claimed |
| US-20120230944-A1 | STABILIZATION AND STORAGE OF BIOLOGICAL PHARMACEUTICAL COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-09-13 | — | — | US | claimed |
| WO-2011069037-A2 | STABILIZATION AND STORAGE OF BIOLOGICAL PHARMACEUTICAL COMPOSITIONS | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2011-06-09 | — | — | WO | claimed |
| EP-0812821-B1 | Carbonic ester of betaine, their preparation and use | AKZO NOBEL NV (NL) | 2000-11-29 | — | — | EP | claimed |
| US-4309205-A | APPLYING AQUEOUS SOLUTION OF CHOLINE SALT TO IMPROVE QUANTITY AND QUALITY OF FLOWERS OR FRUIT | THE STATE OF ISRAEL MINISTRY OF AGRICULTURE (IL) | 1982-01-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12551441-B2 | Water soluble silicon-containing granulate | SI, GIPR, VIP | ADORA3 2072/4885MEN1 2488/4885KMT2A 3323/4885 |
| US-20120230944-A1 | STABILIZATION AND STORAGE OF BIOLOGICAL PHARMACEUTICAL COMPOSITIONS | IL2, IL2RA, IL36G | ADORA3 4286/4885MEN1 2714/4885KMT2A 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.