Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266406 | 0.94 | MAPK8 (0.45) | MAPK8CYP3A4CYP2D6LTA4HTLR8 | |
| SCHEMBL4264852 | 0.89 | MAPK8 (0.43) | MAPK8CYP3A4LTA4HTLR8MCHR1 | |
| SCHEMBL6918344 | 0.81 | CYP3A4 (0.39) | MAPK8SOAT1CYP3A4CYP2D6NR5A1 | |
| SCHEMBL10263555 | 0.81 | MAPK8 (0.42) | MAPK8NPC1LMNACYP1A2NUDT1 | |
| SCHEMBL3430277 | 0.81 | MAPK8 (0.42) | MAPK8SOAT1NPC1LMNACYP1A2 | |
| SCHEMBL9847177 | 0.80 | MAPK8 (0.44) | MAPK8NR5A1NPC1LMNANFKB1 | |
| SCHEMBL6283547 | 0.80 | NUDT1 (0.57) | TLR8MCHR1NUDT1 | |
| SCHEMBL6918342 | 0.80 | MAPK8 (0.45) | MAPK8SOAT1CYP3A4CYP2D6NR5A1 | |
| SCHEMBL8682728 | 0.79 | MAPK8 (0.36) | MAPK8SOAT1CYP3A4CYP2D6LTA4H | |
| SCHEMBL27972350 | 0.79 | CYP3A4 (0.40) | SOAT1CYP3A4CYP2D6NR5A1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11228311-A | — | — | None | — | — | JP | disclosed |
| CN-105536873-B | A kind of composite catalyst and its application | 帕潘纳(北京)科技有限公司 | 2017-11-28 | — | — | CN | disclosed |
| EP-0794177-B1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | AMERICAN CYANAMID CO (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6087498-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| US-5977363-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| JP-H11228311-A | IMPROVEMENT OF RESIDUAL PREVENTION OF MITE AND METHOD FOR KEEPING PLANT PROTECTION FROM PARATISM OF THE SAME | AMERICAN CYANAMID CO | 1999-08-24 | — | — | JP | disclosed |
| EP-0794177-A1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | American Cyanamid Company (US) | 1997-09-10 | — | — | EP | disclosed |