Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22576627 | 0.86 | SMN1; SMN2 (0.41) | MAPK8SMN1; SMN2HSD17B10RXRAGRIN1 | |
| SCHEMBL7029492 | 0.81 | POLB (0.42) | MAPK8SMN1; SMN2RXRAGRIN1GRIN2B | |
| SCHEMBL3513367 | 0.80 | RXRA (0.33) | MAPK8RXRAGRIN1GRIN2B | |
| SCHEMBL7783352 | 0.80 | MAPK8 (0.46) | MAPK8MCHR1CYP19A1NR5A1LTA4H | |
| SCHEMBL6223037 | 0.80 | TSHR (0.38) | SMN1; SMN2HSD17B10RXRAGRIN1GRIN2B | |
| SCHEMBL4582943 | 0.78 | RECQL (0.37) | MAPK8RXRAGRIN1GRIN2B | |
| SCHEMBL84523 | 0.76 | KCNH2 (0.40) | CYP3A4TLR8LMNACYP1A2CYP2C9 | |
| SCHEMBL4860109 | 0.75 | KCNH2 (0.43) | CYP3A4HSD17B10LMNA | |
| SCHEMBL13347716 | 0.75 | PTGS2 (0.46) | MAPK8NR5A1TLR8SMN1; SMN2RXRA | |
| SCHEMBL4541652 | 0.74 | LTA4H (0.44) | MAPK8MCHR1CYP19A1NR5A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734304-B2 | REACTING THE CORRESPONDING 4.6-DIHALOPYRIMIDINE COMPOUND WITH BASE; ONE POT PROCESS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-05-11 | — | — | US | disclosed |
| US-20030092723-A1 | Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092723-A1 | Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives | DPYD, TYMS, TYMP | MAPK8 3389/4885MCHR1 4591/4885CYP19A1 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.