Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | USP28 | Q96RU2 | 4/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125185 | 0.79 | TDP1 (0.42) | LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8804424 | 0.77 | TDP1 (0.41) | LMNAMEN1KMT2A | |
| SCHEMBL21884475 | 0.76 | LMNA (0.42) | IKBKBLMNACHUKKDM1AMEN1 | |
| Hydrochloric Acid SCHEMBL8803119 | 0.74 | LMNA (0.57) | LMNAUSP28GHSRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8804082 | 0.70 | SLC6A9 (0.54) | LMNASLC6A9 | |
| SCHEMBL5173577 | 0.66 | SMN1; SMN2 (0.56) | LMNAKDM1AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8805378 | 0.66 | LMNA (0.40) | LMNAUSP28GHSRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8815239 | 0.65 | SMN1; SMN2 (0.55) | LMNAKDM1AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27677990 | 0.65 | F10 (0.34) | LMNAGHSR | |
| Hydrochloric Acid SCHEMBL8803089 | 0.65 | LMNA (0.40) | LMNAUSP28PTGS2GHSRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140056-A2 | THE UTILISATION OF INHIBITORS OF THE SODIUM HYDROGEN EXCHANGER FOR PRODUCING A MEDICAMENT FOR PREVENTING ORGAN DYSFUNCTIONS AND DISEASES RELATED TO A PARTICULAR AGE AND FOR PROLONGING LIFE | Aventis Pharma Deutschland GmbH (DE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000038661-A2 | THE UTILISATION OF INHIBITORS OF THE SODIUM HYDROGEN EXCHANGER FOR PRODUCING A MEDICAMENT FOR PREVENTING ORGAN DYSFUNCTIONS AND DISEASES RELATED TO A PARTICULAR AGE AND FOR PROLONGING LIFE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-07-06 | — | — | WO | claimed |