SCHEMBL7783885

SCHEMBL7783885

[O]c1ccc(-c2c(F)ccc3ccccc23)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 2/20 0.41
HPRT1 P00492 2/20 0.40
ALDH1A1 P00352 2/20 0.39
HSD17B10 Q99714 2/20 0.39
CYP2A6 P11509 1/20 0.39
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP1B1 Q16678 4/20 0.39
CYP1A1 P04798 3/20 0.39
CYP1A2 P05177 3/20 0.39
WDR5 P61964 1/20 0.39
AHR P35869 2/20 0.38
DNMT1 P26358 1/20 0.38
MAPT P10636 1/20 0.36
PAX8 Q06710 1/20 0.35
GPR84 Q9NQS5 1/20 0.35
XDH P47989 1/20 0.35
PRKDC P78527 1/20 0.35
ABCC1 P33527 1/20 0.35
ABCG2 Q9UNQ0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18165257 0.86 ALDH1A1 (0.44) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL3153755 0.84 ALDH1A1 (0.46) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL29213863 0.81 ESR1 (0.46) HPRT1ALDH1A1HSD17B10CYP2A6TSHR
SCHEMBL7033272 0.77 TRPV6 (0.39) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL22005379 0.74 HPRT1 (0.34) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL3952819 0.71 ALDH1A1 (0.50) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL7719797 0.71 DNMT1 (0.46) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL28596672 0.70 DNMT1 (0.42) CES1HPRT1ALDH1A1HSD17B10CYP2A6
SCHEMBL29216526 0.69 PTPN22 (0.52) HPRT1ALDH1A1HSD17B10CYP2A6TSHR
SCHEMBL8178839 0.68 CA12 (0.58) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140947-A1 METHOD FOR PRODUCING MONO-ORGANOBORANES OR DI-ORGANOBORANES Basell Polyolefine GmbH (DE) 2001-10-10 EP claimed
WO-2000037476-A1 METHOD FOR PRODUCING MONO-ORGANOBORANES OR DI-ORGANOBORANES BASELL POLYOLEFINE GMBH (DE) 2000-06-29 WO claimed