Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.51 |
| ▸ | PDE4A | P27815 | 6/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316971 | 1.00 | PDE4B (0.51) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1388242 | 0.86 | PDE4A (0.54) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1388244 | 0.86 | PDE4A (0.54) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL19076159 | 0.85 | MAPT (0.62) | ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1389073 | 0.85 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1389074 | 0.85 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL8482828 | 0.83 | PDE4A (0.57) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL8482836 | 0.83 | PDE4A (0.57) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1389060 | 0.83 | ALDH1A1 (0.68) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1388171 | 0.83 | ALDH1A1 (0.68) | PDE4BPDE4APDE4DPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640065-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2001-10-17 | — | — | EP | disclosed |
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5633257-A | PHOSPHODIESTERASE INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |