Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517848 | 1.00 | MAPT (0.59) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1566944 | 0.98 | MAPT (0.57) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3783518 | 0.85 | IDO1 (0.46) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3784611 | 0.85 | MAPT (0.45) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3792014 | 0.84 | MAPT (0.46) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL12239184 | 0.84 | S1PR1 (0.57) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3784751 | 0.84 | MAPT (0.46) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2094106 | 0.81 | FPR2 (0.45) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL7790025 | 0.81 | TRPA1 (0.47) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL29793652 | 0.81 | MAPT (0.45) | MAPTMEN1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |