Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | ESR1 | P03372 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207273 | 0.87 | TP53 (0.70) | TP53LMNAHTTESR1TSHR | |
| SCHEMBL5492924 | 0.81 | TP53 (1.00) | TP53LMNAHTTESR1TSHR | |
| SCHEMBL30542082 | 0.81 | TP53 (1.00) | TP53LMNAHTTESR1TSHR | |
| SCHEMBL3317981 | 0.81 | TP53 (1.00) | TP53LMNAHTTESR1TSHR | |
| SCHEMBL3899828 | 0.81 | TP53 (1.00) | TP53LMNAHTTESR1TSHR | |
| SCHEMBL29723016 | 0.81 | TP53 (1.00) | TP53LMNAHTTESR1TSHR | |
| Hydrochloric Acid SCHEMBL27636482 | 0.79 | LMNA (0.96) | TP53LMNAHTTESR1TSHR | |
| Hydrochloric Acid SCHEMBL27636481 | 0.79 | LMNA (0.96) | TP53LMNAHTTESR1TSHR | |
| Hydrochloric Acid SCHEMBL1884136 | 0.79 | LMNA (0.96) | TP53LMNAHTTESR1TSHR | |
| SCHEMBL15440744 | 0.79 | TP53 (0.60) | TP53LMNAHTTTSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625895-B2 | Diphenyl-dihydro-imidazopyridinones | Hoffmann-Le Roche Inc. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625895-B2 | Diphenyl-dihydro-imidazopyridinones | Hoffmann-Le Roche Inc. (US) | 2009-12-01 | — | — | US | disclosed |
| WO-2008125487-A1 | DIPHENYL-DIHYDRO-IMIDAZOPYRIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-23 | — | — | WO | disclosed |
| US-20080255119-A1 | DIPHENYL-DIHYDRO-IMIDAZOPYRIDINONES | DOMINIQUE ROMYR | 2008-10-16 | — | — | US | disclosed |
| US-20080255119-A1 | DIPHENYL-DIHYDRO-IMIDAZOPYRIDINONES | DOMINIQUE ROMYR | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255119-A1 | DIPHENYL-DIHYDRO-IMIDAZOPYRIDINONES | TP53, MDM2, TP53BP1 | TP53 1/4885LMNA 2692/4885HTT 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.