Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787638 | 0.90 | MAPT (0.64) | MAOAMAOBALDH1A1MEN1KMT2A | |
| SCHEMBL18541656 | 0.84 | MAOB (0.56) | MAOAMAOBALDH1A1MEN1KMT2A | |
| SCHEMBL31067505 | 0.82 | MAPT (0.67) | ALDH1A1MEN1KMT2AMAPK1LMNA | |
| SCHEMBL4470153 | 0.82 | MAPT (0.67) | ALDH1A1MEN1KMT2AMAPK1LMNA | |
| SCHEMBL10939515 | 0.82 | SRD5A2 (0.63) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL21567532 | 0.80 | HRH2 (0.61) | MAOBKMT2AMAPK1LMNAL3MBTL1 | |
| SCHEMBL7789171 | 0.79 | MEN1 (0.55) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL2374109 | 0.79 | CHRNB2 (0.70) | MAOBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3234327 | 0.79 | CES2 (0.68) | ALDH1A1MEN1KMT2AMAPK1LMNA | |
| SCHEMBL50488 | 0.79 | GAA (0.72) | ALDH1A1MEN1KMT2AMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |