Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL712969 | 0.88 | NPC1 (0.38) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL29706577 | 0.88 | NPC1 (0.38) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL9257974 | 0.87 | NPC1 (0.31) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL22080465 | 0.86 | NPC1 (0.37) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL24236672 | 0.85 | NPC1 (0.36) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL24236671 | 0.85 | NPC1 (0.36) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL6904762 | 0.85 | NPC1 (0.44) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL9259309 | 0.85 | NR1I2 (0.32) | NPC1RAB9AHSP90AA1ALOX5PTGS2 | |
| SCHEMBL29708 | 0.85 | NPC1 (0.49) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 | |
| SCHEMBL29350736 | 0.85 | NPC1 (0.49) | NPC1RAB9AHSP90AA1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1342748-B1 | Synergistic combinations of UV Absorbers for pigmented polyolefins | CIBA HOLDING INC (CH) | 2008-08-27 | — | — | EP | disclosed |
| EP-1144391-A1 | ONE-POT PROCESS FOR THE PREPARATION OF 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLES | Ciba SC Holding AG (CH) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043376-A1 | ONE-POT PROCESS FOR THE PREPARATION OF 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2000-07-27 | — | — | WO | disclosed |
| US-6040455-A | REACTING A HALOBENZOTRIAZOLE COMPOUND WITH ALIPHATIC, PHENYLALKYL OR ARYL MERCAPTAN COMPOUND TO FORM 5-THIO SUBSTITUTED BENZOTRIAZOLE, OXIDIZING WITH HYDROGEN PEROXIDE TO FOR 5-SULFONE SUBSTITUED BENZOTRIAZOLE COMPOUND | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-03-21 | — | — | US | disclosed |