Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 7/20 | 0.47 |
| ▸ | CA9 | Q16790 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842010 | 0.81 | PDE5A (0.63) | PDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL5596744 | 0.74 | PDE5A (0.62) | PDE5AGAAHDAC1HDAC2HDAC6 | |
| SCHEMBL6642932 | 0.74 | PDE5A (0.81) | PDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL24051300 | 0.71 | PDE5A (0.89) | PDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL6643877 | 0.69 | PDE5A (0.76) | PDE5A | |
| SCHEMBL8149898 | 0.68 | PDE5A (0.70) | PDE5A | |
| SCHEMBL7721640 | 0.68 | PDE5A (0.69) | PDE5ACA12CA9 | |
| SCHEMBL3840503 | 0.67 | PDE5A (0.72) | PDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL6483177 | 0.66 | PDE5A (0.83) | PDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7160531 | 0.66 | PDE5A (0.65) | PDE5ALMNAHDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140044-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | Novartis AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037061-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | NOVARTIS AG (CH) | 2000-06-29 | — | — | WO | disclosed |