Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773108 | 0.89 | MAPT (0.57) | KMT2AMEN1POLBALDH1A1RAB9A | |
| SCHEMBL2990917 | 0.86 | KMT2A (0.81) | KMT2AMEN1POLBRAB9ANPC1 | |
| SCHEMBL13302357 | 0.82 | RAB9A (0.74) | KMT2AMEN1POLBALDH1A1RAB9A | |
| SCHEMBL2993822 | 0.81 | POLB (0.51) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL31296648 | 0.79 | MEN1 (0.55) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL31296647 | 0.79 | MEN1 (0.55) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL2773250 | 0.79 | MEN1 (0.55) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL26116957 | 0.79 | MEN1 (0.55) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL30115032 | 0.77 | MEN1 (0.53) | KMT2AMEN1POLBRAB9ANPC1 | |
| SCHEMBL25501940 | 0.76 | CYP1A2 (0.50) | KMT2AMEN1POLBALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |