Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540196 | 1.00 | ACP3 (0.50) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL7788967 | 0.98 | MAPK1 (0.51) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL7785587 | 0.93 | MAPK1 (0.47) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL27530409 | 0.92 | MAPK1 (0.47) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL7785483 | 0.92 | MAPK1 (0.47) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL7785304 | 0.92 | MAPK1 (0.48) | MAPK1NPSR1ALDH1A1MAPTNPC1 | |
| SCHEMBL27556854 | 0.92 | MAPK1 (0.48) | MAPK1NPSR1ALDH1A1MAPTNPC1 | |
| SCHEMBL7780378 | 0.91 | MAPK1 (0.46) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL7785488 | 0.91 | MAPK1 (0.46) | ACP3MAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL7780401 | 0.90 | CRHBP (0.53) | ACP3ALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |