Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785681 | 1.00 | DRD2 (0.43) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL22702312 | 0.83 | DRD2 (0.57) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL22702276 | 0.83 | DRD2 (0.57) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7785750 | 0.78 | DRD2 (0.70) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7785753 | 0.78 | DRD2 (0.70) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7785706 | 0.76 | DRD2 (0.52) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7785703 | 0.76 | DRD2 (0.52) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7788806 | 0.75 | DRD2 (0.70) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7788808 | 0.75 | DRD2 (0.70) | DRD2DRD1DRD3HTR1ADRD4 | |
| SCHEMBL7786302 | 0.75 | DRD3 (0.44) | DRD2DRD1DRD3HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717620-B1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0717620-A4 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0717620-A1 | SUBSTITUTED 2-AMINOTETRALINS | Discovery Therapeutics, Inc. (US) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995004532-A1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC. (US) | 1995-02-16 | — | — | WO | disclosed |