SCHEMBL7786133

SCHEMBL7786133

CCCCOc1cc(OCCCN2CCOCC2)cc2c1-c1c(OCCCN3CCOCC3)cccc1C2=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.58
MAPK1 P28482 2/20 0.58
SIGMAR1 Q99720 2/20 0.58
HRH3 Q9Y5N1 2/20 0.58
CYP1A2 P05177 1/20 0.58
CHRM2 P08172 1/20 0.58
CHRM1 P11229 1/20 0.58
HTR2A P28223 1/20 0.58
SCN1A P35498 1/20 0.58
HTR2B P41595 1/20 0.58
KCNH2 Q12809 1/20 0.58
SCN2A Q99250 1/20 0.58
SCN3A Q9NY46 1/20 0.58
USP2 O75604 2/20 0.57
LMNA P02545 2/20 0.57
KDM4E B2RXH2 3/20 0.49
HTT P42858 1/20 0.49
CYP2D6 P10635 1/20 0.48
TSHR P16473 1/20 0.48
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7796393 0.96 ALDH1A1 (0.52) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7795911 0.96 ALDH1A1 (0.52) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7796433 0.94 ALDH1A1 (0.55) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7786100 0.93 MAPK1 (0.60) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7786493 0.92 TSHR (0.57) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7786215 0.92 KDM4E (0.55) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7791807 0.91 ALDH1A1 (0.57) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7796357 0.91 KDM4E (0.47) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7786153 0.91 KDM4E (0.47) ALDH1A1MAPK1SIGMAR1HRH3CYP1A2
SCHEMBL7792451 0.91 HRH3 (0.49) ALDH1A1HRH3KCNH2KDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906268-B1 ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS AVENTIS PHARMA INC (US) 2001-11-28 EP disclosed
US-6004959-A HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed