SCHEMBL7786100

SCHEMBL7786100

CCCCOc1cccc2c1-c1c(OCCCN3CCOCC3)cccc1C2=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.60
CYP1A2 P05177 2/20 0.60
ALDH1A1 P00352 2/20 0.60
HRH3 Q9Y5N1 2/20 0.60
CHRM2 P08172 1/20 0.60
CHRM1 P11229 1/20 0.60
HTR2A P28223 1/20 0.60
SCN1A P35498 1/20 0.60
HTR2B P41595 1/20 0.60
KCNH2 Q12809 1/20 0.60
SCN2A Q99250 1/20 0.60
SIGMAR1 Q99720 1/20 0.60
SCN3A Q9NY46 1/20 0.60
USP2 O75604 2/20 0.59
LMNA P02545 1/20 0.59
CYP2D6 P10635 2/20 0.55
TSHR P16473 1/20 0.55
KDM4E B2RXH2 5/20 0.53
CYP2C19 P33261 1/20 0.51
TDP1 Q9NUW8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7796344 0.95 MAPK1 (0.53) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7795850 0.95 TSHR (0.55) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7791839 0.94 MAPK1 (0.56) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7786110 0.93 CYP2D6 (0.55) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7786133 0.93 ALDH1A1 (0.58) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7792140 0.91 CYP2D6 (0.65) CYP1A2ALDH1A1USP2CYP2D6TSHR
SCHEMBL27512822 0.90 MAPK1 (0.49) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7795750 0.90 KDM4E (0.50) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7795928 0.90 TSHR (0.52) MAPK1CYP1A2ALDH1A1HRH3CHRM2
SCHEMBL7791807 0.90 ALDH1A1 (0.57) MAPK1CYP1A2ALDH1A1HRH3CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906268-B1 ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS AVENTIS PHARMA INC (US) 2001-11-28 EP disclosed