Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796300 | 0.94 | CYP2D6 (0.52) | KDM4ESMN1; SMN2ALDH1A1HTTTSHR | |
| SCHEMBL7796201 | 0.94 | KDM4E (0.54) | KDM4EBRD4POLBSMN1; SMN2DRD1 | |
| SCHEMBL7792459 | 0.93 | KDM4E (0.51) | KDM4EBRD4POLBSMN1; SMN2DRD1 | |
| SCHEMBL7795750 | 0.92 | KDM4E (0.50) | KDM4EBRD4POLBSMN1; SMN2DRD1 | |
| SCHEMBL7792380 | 0.91 | CYP2D6 (0.53) | KDM4EBRD4POLBSMN1; SMN2DRD1 | |
| SCHEMBL7794702 | 0.90 | KDM4E (0.46) | KDM4EBRD4POLBSMN1; SMN2DRD1 | |
| SCHEMBL7795930 | 0.90 | KDM4E (0.46) | KDM4EBRD4POLBSMN1; SMN2DRD1 | |
| SCHEMBL7786139 | 0.90 | ALDH1A1 (0.53) | KDM4EPOLBSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7786110 | 0.88 | CYP2D6 (0.55) | KDM4EPOLBSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7786359 | 0.88 | ALDH1A1 (0.52) | KDM4EPOLBSMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |