Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794877 | 0.99 | POLB (0.56) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7792228 | 0.94 | ALDH1A1 (0.54) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7792217 | 0.94 | POLB (0.62) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7794664 | 0.93 | HRH3 (0.55) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7794948 | 0.93 | POLB (0.60) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7792620 | 0.90 | TDP1 (0.49) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7786139 | 0.90 | ALDH1A1 (0.53) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7792380 | 0.90 | CYP2D6 (0.53) | POLBHTR2CALDH1A1CYP2D6TDP1 | |
| SCHEMBL7796096 | 0.89 | LTA4H (0.50) | POLBHTR2CMEN1KMT2AALDH1A1 | |
| SCHEMBL7792704 | 0.89 | SMN1; SMN2 (0.49) | POLBHTR2CMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |