Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792338 | 0.99 | POLB (0.49) | POLBHTR2CKDM4EHTTALDH1A1 | |
| SCHEMBL7791975 | 0.95 | ALDH1A1 (0.49) | POLBKDM4EHTTACHEALDH1A1 | |
| SCHEMBL7794688 | 0.95 | POLB (0.53) | POLBHTR2CMCHR1ACHEMAOB | |
| SCHEMBL7794725 | 0.94 | KDM4E (0.48) | KDM4EHTTACHEALDH1A1TSHR | |
| SCHEMBL7792055 | 0.94 | POLB (0.52) | POLBHTR2CACHEMAOB | |
| SCHEMBL27514211 | 0.93 | ALDH1A1 (0.44) | POLBHTR2CKDM4EHTTACHE | |
| SCHEMBL7786431 | 0.93 | POLB (0.49) | POLBHTR2CACHEMAOB | |
| SCHEMBL7795948 | 0.93 | POLB (0.48) | POLBHTR2CKDM4EHTTALDH1A1 | |
| SCHEMBL7792673 | 0.93 | KDM4E (0.46) | POLBKDM4EHTTACHEALDH1A1 | |
| SCHEMBL7791841 | 0.93 | ALDH1A1 (0.49) | KDM4EHTTALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |