Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791975 | 0.99 | ALDH1A1 (0.49) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7795919 | 0.98 | KDM4E (0.48) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7791841 | 0.97 | ALDH1A1 (0.49) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7794869 | 0.96 | KDM4E (0.46) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7792138 | 0.95 | ALDH1A1 (0.46) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7792338 | 0.95 | POLB (0.49) | KDM4EALDH1A1TSHRHTTHRH3 | |
| SCHEMBL27559437 | 0.95 | ALDH1A1 (0.53) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7792137 | 0.95 | ALDH1A1 (0.53) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7792673 | 0.95 | KDM4E (0.46) | KDM4EALDH1A1TSHRL3MBTL1HTT | |
| SCHEMBL7795877 | 0.94 | POLB (0.47) | KDM4EALDH1A1L3MBTL1SMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| CN-1235969-A | Intermediates used in preparing dihydrobenzolfuran derivatives | SUMITOMO CHEMICAL CO (JP) | 1999-11-24 | — | — | CN | disclosed |
| CN-1220660-A | Alkyloxyamino substituted fluorenones and their use as protein kinase cinhibitors | HOECHST MARION ROUSSEL INC (US) | 1999-06-23 | — | — | CN | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |