SCHEMBL7786334

SCHEMBL7786334

COC=C(C(=O)OC)c1ccccc1COc1cccc(Cl)n1

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 0.39
L3MBTL1 Q9Y468 1/20 0.37
GAA P10253 2/20 0.37
KDM4E B2RXH2 1/20 0.37
KMT2A Q03164 1/20 0.36
TP53 P04637 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7786324 1.00 HIF1A (0.39) HIF1AL3MBTL1GAAKDM4EKMT2A
SCHEMBL7786328 0.91 HIF1A (0.40) HIF1AL3MBTL1GAAKDM4EKMT2A
SCHEMBL7778221 0.90 HIF1A (0.39) HIF1AL3MBTL1GAAKDM4EKMT2A
SCHEMBL7778217 0.90 HIF1A (0.39) HIF1AL3MBTL1GAAKDM4EKMT2A
SCHEMBL12671601 0.88 GABRA5 (0.39) HIF1AKDM4EKMT2A
SCHEMBL9256030 0.88 GABRA5 (0.39) HIF1AKDM4EKMT2A
SCHEMBL7786037 0.87 HIF1A (0.38) HIF1AKMT2A
SCHEMBL7786032 0.87 HIF1A (0.38) HIF1AKMT2A
SCHEMBL20822607 0.85 HIF1A (0.39) HIF1A
SCHEMBL7888095 0.85 HIF1A (0.37) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102115458-B Synthetic method of 3-methoxy-2-aryl methyl acrylate compound 大连九信精细化工有限公司 2019-12-13 CN disclosed
EP-0840726-B1 PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED PYRID-2-YLOXYMETHYL)PHENYLACETATE SYNGENTA LTD (GB) 2001-10-10 EP disclosed
US-6015905-A REACTING OXY-METAL DERIVATIVE OF A DISUBSTITUTED PYRIDINE WITH METHYL ESTER OF PHENYLACETIC ACID(WHICH ALSO HAS ALKYL SUBSTITUENT ON RING) YIELDS INTERMEDIATE FOR PREPARATION OF AGRICULTURAL FUNGICIDES ZENECA LIMITED 2000-01-18 US disclosed
EP-0840726-A1 PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED PYRID-2-YLOXYMETHYL)PHENYLACETATE ZENECA LIMITED (GB) 1998-05-13 EP disclosed
WO-1997001538-A1 PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED PYRID-2-YLOXYMETHYL)PHENYLACETATE ZENECA LIMITED (GB) 1997-01-16 WO disclosed