Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814818 | 0.95 | RAB9A (0.65) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL3164500 | 0.84 | ALDH1A1 (0.66) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL6814579 | 0.83 | RAB9A (0.61) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL1455315 | 0.82 | MAPT (0.77) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL6811528 | 0.81 | RAB9A (0.64) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL14522042 | 0.81 | RAB9A (0.58) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL6819245 | 0.80 | MAPT (0.61) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL5668091 | 0.79 | MEN1 (0.70) | SMN1; SMN2MAPTRAB9ANPC1KMT2A | |
| SCHEMBL2333062 | 0.78 | HTT (0.61) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL5666338 | 0.77 | KMT2A (0.78) | SMN1; SMN2RAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144397-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144397-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034258-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |